The £75million signing was in line to make his Premier League debut for the club, however pre-match reports that he is struggling with a tight hamstring have been confirmed and he misses out.
The former Southampton defender was seen arriving at Anfield before the game, but did so separately from the rest of the squad.
Dejan Lovren comes into the starting XI alongside Joel Matip for Jurgen Klopp’s side.
For the visitors, Sergio Aguero leads the line having had to make do with an appearance off the bench against Bristol City in midweek.
Liverpool are seeking revenge having been beaten 5-0 by Manchester City earlier this season.